Orally. The dosage depends on the intensity of pain and the patient’s individual sensitivity to treatment. Adults and youth from 12 years of age . The usual starting dose for opioid-naïve patients is 10 mg every 12 hours. Some patients may respond to an initial dose of 5 mg, which reduces the incidence of side effects. Patients already taking opioids may be initiated on higher doses given their previous experience with opioid treatment. A dose of 10-13 mg of oxycodone hydrochloride in the prolonged-release form corresponds to approximately 20 mg of morphine sulfate in the prolonged-release form.